Researcher 1: Neurobiology

This position is in a laboratory of Dr. Michael Lee who is interested defining the pathologic mechanisms for Alzheimer's Disease (AD) and Parkinson's Disease (PD) using cellular and transgenic mouse models. The candidate will work with one of the Senior Scientist/Postdoctoral Scientist under the Principal Investigator. The candidate will perform complex procedures such as screening and maintaining multiple transgenic mouse cohorts, routine behavioral observations and testing, preparation of mouse tissues for histological and biochemical analysis, perform biochemical and histological analysis of mouse brains, and establishing and analysis of tissue culture models.

(45% effort) Aid and/or perform biochemical and histological analysis of mouse brain. Perform euthanasia and fixation of mouse brain. Perform routine histochemical and immunohistochemical analysis, including immunofluorescence analysis. The latter task will require development of immunohistochemical procedures for new antigens, preliminary analysis of the histological sections, and imaging of the tissues using confocal microscopy. Perform mouse brain dissections and subcellular fractionations for immunoblot and/or proteomic analysis. Perform immunoblot and/or other biochemical analysis of mouse brain fractions.

(35% effort) Manage transgenic mouse colony and perform behavioral observations. Perform mouse husbandry, including setting-up mating, weaning offsprings, and collection of tail biopsies. Identify transgenic mice by purification and isolation of tail DNA and analysis via PCR and agarose gel electrophoresis. The person will evaluate/analyze the results of the PCR screening and enter the results into the mouse colony data base.
Perform routine subjective monitoring of transgenic mouse cohorts for development of motoric abnormalities. Perform standardized assessment of motoric function and cognitive function. This task will also require basic statistical analysis (calculations of mean, standard deviation, basic graphing and other functions using MS-excel and/or Graph-Pad software) of collected data. The person will also aid and/or perform pharmaceutical treatment(s) of transgenic and non-transgenic mouse.

(15%) Aid and/or perform cell culture studies. Maintain cultures of various cell lines required for experimental studies, establish primary neural cell cultures, and perform biochemical and histological analysis.

(5% effort) Prepare weekly progress to present at weekly lab meetings.

All required qualifications must be documented on application materials

Required Qualifications:
* Bachelor's degree in Neuroscience or related field (e.g. Biology, Psychology) or a combination of related education and work experience to equal four years.
* Must be willing to work with mouse model of Alzheimer's disease and Parkinson's Disease.

Preferred Qualifications:
Prior laboratory experience with rodent handling/behavior, cell culture, biochemistry, and/or molecular biology.

The Department of Neuroscience is committed to providing excellence in research, education, and public service. The Department of Neuroscience is part of the University of Minnesota's Medical School. The Medical School and related healthcare professional schools are grouped under the Academic Health Center.

The Mission of the Department of Neuroscience

1. Conduct outstanding neuroscience research.
2. Be an educational resource to the Medical School and the University by providing neuroscience education to undergraduate, medical, dental, graduate, and post-graduate students.
3. Provide leadership and be a focal point for the strengthening of neuroscience across the University by enhancing research, educational, and funding opportunities.
4. Intentionally improve inclusivity by valuing diverse perspectives and actively supporting historically marginalized researchers, students, and neuroscience community members.
5. Provide a bridge for the transfer of advances in basic neuroscience into clinical practice with the goal of improving the health of the people of Minnesota.
6. Enhance the understanding and appreciation of neuroscience by the people of Minnesota.

Pay Range: $21.63/hour ($45,000 annually) to $24.04 ($50,000 annually); depending on education/qualifications/experience

Time Appointment: 75%-100% Appointment

Position Type: Civil-Service & Non-Faculty Labor Represented Staff

Please visit the Office of Human Resources website for more information regarding benefit eligibility.

The University offers a comprehensive benefits package that includes:

• Competitive wages, paid holidays, and generous time off
• Continuous learning opportunities through professional training and degree-seeking programs supported by the Regents Tuition Benefit Program
• Low-cost medical, dental, and pharmacy plans
• Healthcare and dependent care flexible spending accounts
• University HSA contributions
• Disability and employer-paid life insurance
• Employee wellbeing program
• Excellent retirement plans with employer contribution
• Public Service Loan Forgiveness (PSLF) opportunity
• Financial counseling services
• Employee Assistance Program with eight sessions of counseling at no cost
• Employee Transit Pass with free or reduced rates in the Twin Cities metro area

Applications must be submitted online. To be considered for this position, please click the Apply button and follow the instructions. You will be given the opportunity to complete an online application for the position and attach a cover letter and resume.

Additional documents may be attached after application by accessing your "My Job Applications" page and uploading documents in the "My Cover Letters and Attachments" section.

To request an accommodation during the application process, please e-mail employ@umn.edu or call (612) 624-8647.

The University recognizes and values the importance of diversity and inclusion in enriching the employment experience of its employees and in supporting the academic mission. The University is committed to attracting and retaining employees with varying identities and backgrounds.

The University of Minnesota provides equal access to and opportunity in its programs, facilities, and employment without regard to race, color, creed, religion, national origin, gender, age, marital status, disability, public assistance status, veteran status, sexual orientation, gender identity, or gender expression. To learn more about diversity at the U: http://diversity.umn.edu

Any offer of employment is contingent upon the successful completion of a background check. Our presumption is that prospective employees are eligible to work here. Criminal convictions do not automatically disqualify finalists from employment.

The University of Minnesota, Twin Cities (UMTC)

The University of Minnesota, Twin Cities (UMTC), is among the largest public research universities in the country, offering undergraduate, graduate, and professional students a multitude of opportunities for study and research. Located at the heart of one of the nation's most vibrant, diverse metropolitan communities, students on the campuses in Minneapolis and St. Paul benefit from extensive partnerships with world-renowned health centers, international corporations, government agencies, and arts, nonprofit, and public service organizations.

At the University of Minnesota, we are proud to be recognized by the Star Tribune as a Top Workplace for 2021, as well as by Forbes as Best Employers for Women and one of America's Best Employers (2015, 2018, 2019, 2023), Best Employer for Diversity (2019, 2020), Best Employer for New Grads (2018, 2019), and Best Employer by State (2019, 2022).