Scientist, Medicinal Chemistry

We are seeking a talented and passionate scientist to join our Chemical Sciences group within Medicinal Chemistry. Using strong organic synthesis skills, you will contribute to developing and supporting novel chemistry solutions for the advancement of our RNAi platform. The successful candidate will have a strong background in synthetic Organic Chemistry with a creative mindset, independent problem-solving ability, and desire to enable discoveries at the bench.

This position is onsite and will be primarily located in Cambridge, MA.

Key Responsibilities

* Develop and execute syntheses of novel chemical modifications and delivery modalities for siRNA
* Multi-step synthesis, purification, and structural analysis of intermediate compounds
* Synthesis of organic building blocks to be used for RNA delivery
* Work closely with our internal RNAi platform teams and external collaborators to discuss project plans and coordinate activities for delivery and activity determination of siRNA
* Troubleshoot and perform routine maintenance on critical instrumentation such as NMR, HPLC, LCMS and other instruments in the lab
* Analyze, interpret, and organize data to prepare clearly articulated experimental reports and communicate the results of the projects at internal meetings

Qualifications

* The ideal candidate will have a Ph.D. in Chemistry and 0-4 years of post-doctoral laboratory research experience in multi-step total synthesis or methodology projects
* Demonstrated ability to understand reaction mechanism and chemical reactivity in Organic Chemistry is a must
* Strong laboratory skills in synthesis, purification, and characterization of small molecules
* Expertise in state-of-the-art analytical techniques such as LC, MS, NMR, and the ability to analyze, interpret, and present data are a prerequisite
* Must be flexible to be able to apply her/his knowledge to new areas of study, thrive in a team environment, and possess excellent communication skills (both written and oral)

About Alnylam:Alnylam Pharmaceuticals (Nasdaq: ALNY) has led the translation of RNA interference (RNAi) into a whole new class of innovative medicines with the potential to transform the lives of people afflicted with rare and more prevalent diseases. Based on Nobel Prize-winning science, RNAi therapeutics represent a powerful, clinically validated approach to treating diseases at their genetic source by "interfering" with mRNA that cause or contribute to disease. Since our founding in 2002, Alnylam has led the RNAi Revolution and continues to turn scientific possibility into reality.

Our culture:Our people-first culture is guided by our core values: fiercely innovative, open culture, purposeful urgency, passion for excellence, and commitment to people, and these values influence how we work and the business decisions we make. Thanks to feedback from our employees over the years, we've been fortunate to be named a top employer around the world. Alnylam is extremely proud to have been recognized as one of Science Magazine's Top Biopharma Employers, one of America's Most Responsible Companies for 2024 by Newsweek, a Fast Company Best Workplace for Innovators, and a Great Place to Work in Canada, France, Italy, Spain, Switzerland, and UK - among others.

At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. We are dedicated to building an environment where employees can feel that they belong, can bring their authentic selves to work, and achieve to their full potential. By empowering employees to embrace their unique differences at work, our business grows stronger with advanced and original thinking, allowing us to bring groundbreaking medicines to patients.